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2017 ; 469
(3-4
): 455-463
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The role of macrophages in skin homeostasis
#MMPMID28233123
Yanez DA
; Lacher RK
; Vidyarthi A
; Colegio OR
Pflugers Arch
2017[Apr]; 469
(3-4
): 455-463
PMID28233123
show ga
The skin and its appendages comprise the largest and fastest growing organ in the
body. It performs multiple tasks and maintains homeostatic control, including the
regulation of body temperature and protection from desiccation and from pathogen
invasion. The skin can perform its functions with the assistance of different
immune cell populations. Monocyte-derived cells are imperative for the completion
of these tasks. The comprehensive role of macrophages and Langerhans cells in
establishing and maintaining skin homeostasis remains incompletely defined.
However, over the past decade, innovations in mouse genetics have allowed for
advancements in the field. In this review, we explore different homeostatic roles
of macrophages and Langerhans cells, including wound repair, follicle
regeneration, salt balance, and cancer regression and progression in the skin.
The understanding of the precise functions of myeloid-derived cells in the skin
under basal conditions can help develop specific therapies that aid in skin and
hair follicle regeneration and cutaneous cancer prevention.
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