Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28944270
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
The role of leptin in health and disease
#MMPMID28944270
Ramos-Lobo AM
; Donato J Jr
Temperature (Austin)
2017[]; 4
(3
): 258-291
PMID28944270
show ga
Leptin is a master regulator of energy balance and body adiposity. Additionally,
leptin exerts important control on glucose homeostasis, thermogenesis, autonomic
nervous system and neuroendocrine axes. In metabolic diseases, such as obesity
and diabetes mellitus, leptin signaling may be compromised, indicating the
important role of this hormone in the etiology and pathophysiological
manifestations of these conditions. In the present manuscript, we reviewed
important concepts of leptin signaling, as well as about the effects of leptin on
several biologic functions. We also discussed the possible therapeutic use of
leptin administration and how our current obesogenic environment contributes to
the development of leptin resistance. Our objective was to provide a
comprehensive and state-of-the-art review about the importance of leptin to
maintain the homeostasis and during pathological conditions.
free
free
free
