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2016 ; 73
(11-12
): 2285-308
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The role of glycine in regulated cell death
#MMPMID27066896
Weinberg JM
; Bienholz A
; Venkatachalam MA
Cell Mol Life Sci
2016[Jun]; 73
(11-12
): 2285-308
PMID27066896
show ga
The cytoprotective effects of glycine against cell death have been recognized for
over 28 years. They are expressed in multiple cell types and injury settings that
lead to necrosis, but are still not widely appreciated or considered in the
conceptualization of cell death pathways. In this paper, we review the available
data on the expression of this phenomenon, its relationship to major
pathophysiologic pathways that lead to cell death and immunomodulatory effects,
the hypothesis that it involves suppression by glycine of the development of a
hydrophilic death channel of molecular dimensions in the plasma membrane, and
evidence for its impact on disease processes in vivo.