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2016 ; 199
(ä): 136-143
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The role of cholesterol in membrane fusion
#MMPMID27179407
Yang ST
; Kreutzberger AJB
; Lee J
; Kiessling V
; Tamm LK
Chem Phys Lipids
2016[Sep]; 199
(ä): 136-143
PMID27179407
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Cholesterol modulates the bilayer structure of biological membranes in multiple
ways. It changes the fluidity, thickness, compressibility, water penetration and
intrinsic curvature of lipid bilayers. In multi-component lipid mixtures,
cholesterol induces phase separations, partitions selectively between different
coexisting lipid phases, and causes integral membrane proteins to respond by
changing conformation or redistribution in the membrane. But, which of these
often overlapping properties are important for membrane fusion?-Here we review a
range of recent experiments that elucidate the multiple roles that cholesterol
plays in SNARE-mediated and viral envelope glycoprotein-mediated membrane fusion.