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10.1007/s12072-016-9723-8 http://scihub22266oqcxt.onion/10.1007/s12072-016-9723-8 C5003899!5003899 !27048617     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27048617 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27048617 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hepatol+Int 2016 ; 10 (5 ): 733-40 Nephropedia Template TP {{tp|p=27048617 |t=2016. The role of bile salts in liver regeneration |pdf=|usr=}}{{27048617 }} gab.com Text The role of bile salts in liver regeneration JO: Hepatol Int http://www.kidney.de/pget.php?&tw=1&pmid=27048617 #FOAvip A growing body of evidence has demonstrated that bile salts are important for liver regeneration following partial hepatectomy. The relative bile salt overload after partial liver resection causes activation of bile salt receptors in non-parenchymal (viz. the plasma membrane receptor TGR5) and parenchymal (viz. the intracellular receptor FXR) cells in the liver, thus, providing signals to the regenerative process. Impaired bile salt signaling in mice with genetic deficiency of Tgr5 or Fxr results in delayed liver regeneration after partial hepatectomy, and is accompanied by mortality in case of Fxr knock-out mice. Conversely, compensatory liver re-growth in hepatectomized mice can be stimulated by feeding of bile salts or alisol B 23-acetate, a natural triterpenoid agonist of Fxr. A large number of animal studies underscore the importance of strict maintenance of bile salt homeostasis for proper progression of liver regeneration. Both ileal and hepatic Fxr play a key role in regulation of bile salt homeostasis and, thus, preventing hepatotoxicity caused by excessive levels of bile salts. They further contribute to liver regeneration by induction of mitogenic factors. Agents that target bile salt receptors hold promise as drugs to stimulate liver regeneration in selected patients. Twit Text FOAVip The role of bile salts in liver regeneration ????Hepatol Int http://www.kidney.de/pget.php?&tw=1&pmid=27048617 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27048617 #FOAvip English Wikipedia <ref>{{Cite pmid|27048617 }}</ref> The role of bile salts in liver regeneration #MMPMID27048617 van de Laarschot LF ; Jansen PL ; Schaap FG ; Olde Damink SW Hepatol Int 2016[Sep]; 10 (5 ): 733-40 PMID27048617 show ga A growing body of evidence has demonstrated that bile salts are important for liver regeneration following partial hepatectomy. The relative bile salt overload after partial liver resection causes activation of bile salt receptors in non-parenchymal (viz. the plasma membrane receptor TGR5) and parenchymal (viz. the intracellular receptor FXR) cells in the liver, thus, providing signals to the regenerative process. Impaired bile salt signaling in mice with genetic deficiency of Tgr5 or Fxr results in delayed liver regeneration after partial hepatectomy, and is accompanied by mortality in case of Fxr knock-out mice. Conversely, compensatory liver re-growth in hepatectomized mice can be stimulated by feeding of bile salts or alisol B 23-acetate, a natural triterpenoid agonist of Fxr. A large number of animal studies underscore the importance of strict maintenance of bile salt homeostasis for proper progression of liver regeneration. Both ileal and hepatic Fxr play a key role in regulation of bile salt homeostasis and, thus, preventing hepatotoxicity caused by excessive levels of bile salts. They further contribute to liver regeneration by induction of mitogenic factors. Agents that target bile salt receptors hold promise as drugs to stimulate liver regeneration in selected patients. |Animals [MESH] |Bile Acids and Salts/*metabolism [MESH] |Hepatectomy [MESH] |Humans [MESH] |Liver Regeneration/*physiology [MESH] |Mice [MESH] |Receptors, Cytoplasmic and Nuclear/metabolism [MESH] |Receptors, G-Protein-Coupled/metabolism [MESH]The role of bile salts in liver regeneration (epmc).pdf DeepDyve Pubget Overpricing