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2017 ; 8
(2
): 91-98
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The role of alternative splicing in cancer
#MMPMID28005460
Singh B
; Eyras E
Transcription
2017[Mar]; 8
(2
): 91-98
PMID28005460
show ga
The functional capacity of cells is defined by the transcriptome. Many recent
studies have identified variations in the transcriptome of tumors due to
alternative splicing changes, as well as mutations in splicing factors and
regulatory signals in most tumor types. Some of these alterations have been
linked to tumor progression, metastasis, therapy resistance, and other oncogenic
processes. Here, we describe the different mechanisms that drive splicing changes
in tumors and their impact in cancer. Motivated by the current evidence, we
propose a model whereby a subset of the splicing patterns contributes to the
definition of specific tumor phenotypes, and may hold potential for the
development of novel clinical biomarkers and therapeutic approaches.
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