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The role of Notch signalling in ovarian angiogenesis
#MMPMID28284219
Xie Q
; Cheng Z
; Chen X
; Lobe CG
; Liu J
J Ovarian Res
2017[Mar]; 10
(1
): 13
PMID28284219
show ga
In adults, the ovary is characterized with extensive angiogenesis and regular
intervals of rapid growth. Ovarian function is dependent on the network of
angiogenic vessels which enable the follicle and/or corpus luteum to receive
oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the
induction and development of pathological ovary, such as polycystic ovary
syndrome and ovarian cancer. Notch signalling pathway is one of the primary
regulators of angiogenesis and a therapeutic target for ovarian diseases. Here,
we will review literatures on the expression pattern of Notch pathway components
in the ovary and on the role of Notch signalling pathway on ovarian angiogenesis.