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10.1016/j.tips.2015.05.007

http://scihub22266oqcxt.onion/10.1016/j.tips.2015.05.007
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suck abstract from ncbi


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pmid26071118
      Trends+Pharmacol+Sci 2015 ; 36 (9 ): 568-78
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  • The role of H2S bioavailability in endothelial dysfunction #MMPMID26071118
  • Wang R ; Szabo C ; Ichinose F ; Ahmed A ; Whiteman M ; Papapetropoulos A
  • Trends Pharmacol Sci 2015[Sep]; 36 (9 ): 568-78 PMID26071118 show ga
  • Endothelial dysfunction (EDF) reflects pathophysiological changes in the phenotype and functions of endothelial cells that result from and/or contribute to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide (H2S) in the pathogenesis of EDF, one of the fastest advancing research topics. Conventionally treated as an environment pollutant, H2S is also produced in endothelial cells and participates in the fine regulation of endothelial integrity and functions. Disturbed H2S bioavailability has been suggested to be a novel indicator of EDF progress and prognosis. EDF manifests in different forms in multiple pathologies, but therapeutics aimed at remedying altered H2S bioavailability may benefit all.
  • |Animals [MESH]
  • |Endothelium, Vascular/*metabolism/physiology/physiopathology [MESH]
  • |Free Radicals/metabolism [MESH]
  • |Humans [MESH]
  • |Hydrogen Sulfide/*metabolism [MESH]


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