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2015 ; 36
(9
): 568-78
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The role of H2S bioavailability in endothelial dysfunction
#MMPMID26071118
Wang R
; Szabo C
; Ichinose F
; Ahmed A
; Whiteman M
; Papapetropoulos A
Trends Pharmacol Sci
2015[Sep]; 36
(9
): 568-78
PMID26071118
show ga
Endothelial dysfunction (EDF) reflects pathophysiological changes in the
phenotype and functions of endothelial cells that result from and/or contribute
to a plethora of cardiovascular diseases. We review the role of hydrogen sulfide
(H2S) in the pathogenesis of EDF, one of the fastest advancing research topics.
Conventionally treated as an environment pollutant, H2S is also produced in
endothelial cells and participates in the fine regulation of endothelial
integrity and functions. Disturbed H2S bioavailability has been suggested to be a
novel indicator of EDF progress and prognosis. EDF manifests in different forms
in multiple pathologies, but therapeutics aimed at remedying altered H2S
bioavailability may benefit all.