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2015 ; 63
(1-3
): 153-66
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The role of B-1 cells in inflammation
#MMPMID26427372
Aziz M
; Holodick NE
; Rothstein TL
; Wang P
Immunol Res
2015[Dec]; 63
(1-3
): 153-66
PMID26427372
show ga
B-1 lymphocytes exhibit unique phenotypic, ontogenic, and functional
characteristics that differ from the conventional B-2 cells. B-1 cells
spontaneously secrete germline-like, repertoire-skewed polyreactive natural
antibody, which acts as a first line of defense by neutralizing a wide range of
pathogens before launching of the adaptive immune response. Immunomodulatory
molecules such as interleukin-10, adenosine, granulocyte-macrophage
colony-stimulating factor, interleukin-3, and interleukin-35 are also produced by
B-1 cells in the presence or absence of stimulation, which regulate acute and
chronic inflammatory diseases. Considerable progress has been made during the
past three decades since the discovery of B-1 cells, which has improved not only
our understanding of their phenotypic and ontogenic uniqueness but also their
role in various inflammatory diseases including influenza, pneumonia, sepsis,
atherosclerosis, inflammatory bowel disease, autoimmunity, obesity and diabetes
mellitus. Recent identification of human B-1 cells widens the scope of this
field, leading to novel innovations that can be implemented from bench to
bedside. Among the vast number of studies on B-1 cells, we have carried out a
literature review highlighting current trends in the study of B-1 cell
involvement during inflammation, which may result in a paradigm shift toward
sustainable therapeutics in various inflammatory diseases.
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