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10.1155/2015/434389 http://scihub22266oqcxt.onion/10.1155/2015/434389 C4605147!4605147 !26491648     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26491648 &cmd=llinks): Failed to open stream: HTTP request failed! 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The role of "bone immunological niche" for a new pathogenetic paradigm of osteoporosis |pdf=|usr=}}{{26491648 }} gab.com Text The role of "bone immunological niche" for a new pathogenetic paradigm of osteoporosis JO: Anal Cell Pathol (Amst) http://www.kidney.de/pget.php?&tw=1&pmid=26491648 #FOAvip Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. The etiology and pathogenetic mechanisms of osteoporosis have not been clearly elucidated. Osteoporosis is linked to bone resorption by the activation of the osteoclastogenic process. The breakdown of homeostasis among pro- and antiosteoclastogenic cells causes unbalanced bone remodeling. The complex interactions among these cells in the bone microenvironment involve several mediators and proinflammatory pathways. Thus, we may consider the bone microenvironment as a complex system in which local and systemic immunity are regulated and we propose to consider it as an "immunological niche." The study of the "bone immunological niche" will permit a better understanding of the complex cell trafficking which regulates bone resorption and disease. The goal of a perfect therapy for osteoporosis would be to potentiate good cells and block the bad ones. In this scenario, additional factors may take part in helping or hindering the proosteoblastogenic factors. Several proosteoblastogenic and antiosteoclastogenic agents have already been identified and some have been developed and commercialized as biological therapies for osteoporosis. Targeting the cellular network of the "bone immunological niche" may represent a successful strategy to better understand and treat osteoporosis and its complications. Twit Text FOAVip The role of "bone immunological niche" for a new pathogenetic paradigm of osteoporosis ????Anal Cell Pathol (Amst) http://www.kidney.de/pget.php?&tw=1&pmid=26491648 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26491648 #FOAvip English Wikipedia <ref>{{Cite pmid|26491648 }}</ref> The role of "bone immunological niche" for a new pathogenetic paradigm of osteoporosis #MMPMID26491648 Pagliari D ; Ciro Tamburrelli F ; Zirio G ; Newton EE ; Cianci R Anal Cell Pathol (Amst) 2015[]; 2015 (ä): 434389 PMID26491648 show ga Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. The etiology and pathogenetic mechanisms of osteoporosis have not been clearly elucidated. Osteoporosis is linked to bone resorption by the activation of the osteoclastogenic process. The breakdown of homeostasis among pro- and antiosteoclastogenic cells causes unbalanced bone remodeling. The complex interactions among these cells in the bone microenvironment involve several mediators and proinflammatory pathways. Thus, we may consider the bone microenvironment as a complex system in which local and systemic immunity are regulated and we propose to consider it as an "immunological niche." The study of the "bone immunological niche" will permit a better understanding of the complex cell trafficking which regulates bone resorption and disease. The goal of a perfect therapy for osteoporosis would be to potentiate good cells and block the bad ones. In this scenario, additional factors may take part in helping or hindering the proosteoblastogenic factors. Several proosteoblastogenic and antiosteoclastogenic agents have already been identified and some have been developed and commercialized as biological therapies for osteoporosis. Targeting the cellular network of the "bone immunological niche" may represent a successful strategy to better understand and treat osteoporosis and its complications. |Biological Factors/therapeutic use [MESH] |Bone Resorption/immunology [MESH] |Bone and Bones/*immunology/*pathology [MESH] |Humans [MESH] |Osteoporosis/drug therapy/*immunology [MESH]The role of "bone immunological niche" for a new pathogenetic paradigm(epmc).pdf DeepDyve Pubget Overpricing