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2016 ; 8
(5
): 366-77
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The reverse control of irreversible biological processes
#MMPMID27327189
Cho KH
; Joo JI
; Shin D
; Kim D
; Park SM
Wiley Interdiscip Rev Syst Biol Med
2016[Sep]; 8
(5
): 366-77
PMID27327189
show ga
Most biological processes have been considered to be irreversible for a long
time, but some recent studies have shown the possibility of their reversion at a
cellular level. How can we then understand the reversion of such biological
processes? We introduce a unified conceptual framework based on the attractor
landscape, a molecular phase portrait describing the dynamics of a molecular
regulatory network, and the phenotype landscape, a map of phenotypes determined
by the steady states of particular output molecules in the attractor landscape.
In this framework, irreversible processes involve reshaping of the phenotype
landscape, and the landscape reshaping causes the irreversibility of processes.
We suggest reverse control by network rewiring which changes network dynamics
with constant perturbation, resulting in the restoration of the original
phenotype landscape. The proposed framework provides a conceptual basis for the
reverse control of irreversible biological processes through network rewiring.
WIREs Syst Biol Med 2016, 8:366-377. doi: 10.1002/wsbm.1346 For further resources
related to this article, please visit the WIREs website.
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