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10.1111/j.1582-4934.2010.01191.x

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suck abstract from ncbi


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pmid21029369
      J+Cell+Mol+Med 2010 ; 14 (12 ): 2697-701
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  • The relationship between early embryo development and tumourigenesis #MMPMID21029369
  • Ma Y ; Zhang P ; Wang F ; Yang J ; Yang Z ; Qin H
  • J Cell Mol Med 2010[Dec]; 14 (12 ): 2697-701 PMID21029369 show ga
  • With the recent substantial progress in developmental biology and cancer biology, the similarities between early embryo development and tumourigenesis, as well as the important interaction between tumours and embryos become better appreciated. In this paper, we review in detail the embryonic origin of tumour, and the similarities between early embryo development and tumourigenesis with respect to cell invasive behaviours, epigenetic regulation, gene expression, protein profiling and other important biological behaviours. Given an improved understanding of the relationship between early embryo development and tumourigenesis, now we have better and broader resources to attack cancer from the perspective of developmental biology and develop next generation of prognostic and therapeutic approaches for this devastating disease.
  • |*Cell Transformation, Neoplastic/genetics/metabolism/pathology [MESH]
  • |*Embryo, Mammalian [MESH]
  • |*Embryonic Development/genetics/physiology [MESH]
  • |*Neoplasms/genetics/metabolism/pathology [MESH]
  • |Animals [MESH]
  • |Biomarkers, Tumor [MESH]
  • |Epigenesis, Genetic [MESH]
  • |Gene Expression [MESH]
  • |Gene Expression Regulation, Developmental [MESH]
  • |Gene Expression Regulation, Neoplastic [MESH]
  • |Humans [MESH]


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