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2010 ; 14
(12
): 2697-701
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The relationship between early embryo development and tumourigenesis
#MMPMID21029369
Ma Y
; Zhang P
; Wang F
; Yang J
; Yang Z
; Qin H
J Cell Mol Med
2010[Dec]; 14
(12
): 2697-701
PMID21029369
show ga
With the recent substantial progress in developmental biology and cancer biology,
the similarities between early embryo development and tumourigenesis, as well as
the important interaction between tumours and embryos become better appreciated.
In this paper, we review in detail the embryonic origin of tumour, and the
similarities between early embryo development and tumourigenesis with respect to
cell invasive behaviours, epigenetic regulation, gene expression, protein
profiling and other important biological behaviours. Given an improved
understanding of the relationship between early embryo development and
tumourigenesis, now we have better and broader resources to attack cancer from
the perspective of developmental biology and develop next generation of
prognostic and therapeutic approaches for this devastating disease.