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2014 ; 30
(ä): 2-13
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The regulation of spermatogenesis by androgens
#MMPMID24598768
Smith LB
; Walker WH
Semin Cell Dev Biol
2014[Jun]; 30
(ä): 2-13
PMID24598768
show ga
Testosterone is essential for maintaining spermatogenesis and male fertility.
However, the molecular mechanisms by which testosterone acts have not begun to be
revealed until recently. With the advances obtained from the use of transgenic
mice lacking or overexpressing the androgen receptor, the cell specific targets
of testosterone action as well as the genes and signaling pathways that are
regulated by testosterone are being identified. In this review, the critical
steps of spermatogenesis that are regulated by testosterone are discussed as well
as the intracellular signaling pathways by which testosterone acts. We also
review the functional information that has been obtained from the knock out of
the androgen receptor from specific cell types in the testis and the genes found
to be regulated after altering testosterone levels or androgen receptor
expression.