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2017 ; 43
(ä): 63-70
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The readily releasable pool of synaptic vesicles
#MMPMID28103533
Kaeser PS
; Regehr WG
Curr Opin Neurobiol
2017[Apr]; 43
(ä): 63-70
PMID28103533
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Each presynaptic bouton is densely packed with many vesicles, only a small
fraction of which are available for immediate release. These vesicles constitute
the readily releasable pool (RRP). The RRP size, and the probability of release
of each vesicle within the RRP, together determine synaptic strength. Here, we
discuss complications and recent advances in determining the size of the
physiologically relevant RRP. We consider molecular mechanisms to generate and
regulate the RRP, and discuss the relationship between vesicle docking and the
RRP. We conclude that many RRP vesicles are docked, that some docked vesicles may
not be part of the RRP, and that undocked vesicles can contribute to the RRP by
rapid recruitment to unoccupied, molecularly activated ready-to-release sites.