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10.2217/epi-2015-0016 http://scihub22266oqcxt.onion/10.2217/epi-2015-0016 C5066125!5066125 !27337224     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27337224 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27337224 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Epigenomics 2016 ; 8 (6 ): 831-42 Nephropedia Template TP {{tp|p=27337224 |t=2016. The promise of epigenomic therapeutics in pancreatic cancer |pdf=|usr=}}{{27337224 }} gab.com Text The promise of epigenomic therapeutics in pancreatic cancer JO: Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=27337224 #FOAvip Pancreatic ductal adenocarcinoma (PDAC) is often viewed to arise primarily by genetic alterations. However, today we know that many aspects of the cancer phenotype require a crosstalk among these genetic alterations with epigenetic changes. Indeed, aberrant gene expression patterns, driven by epigenetics are fixed by altered signaling from mutated oncogenes and tumor suppressors to define the PDAC phenotype. This conceptual framework may have significant mechanistic value and could offer novel possibilities for treating patients affected with PDAC. In fact, extensive investigations are leading to the development of small molecule drugs that reversibly modify the epigenome. These new 'epigenetic therapeutics' discussed herein are promising to fuel a new era of studies, by providing the medical community with new tools to treat this dismal disease. Twit Text FOAVip The promise of epigenomic therapeutics in pancreatic cancer ????Epigenomics http://www.kidney.de/pget.php?&tw=1&pmid=27337224 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27337224 #FOAvip English Wikipedia <ref>{{Cite pmid|27337224 }}</ref> The promise of epigenomic therapeutics in pancreatic cancer #MMPMID27337224 Lomberk GA ; Iovanna J ; Urrutia R Epigenomics 2016[Jun]; 8 (6 ): 831-42 PMID27337224 show ga Pancreatic ductal adenocarcinoma (PDAC) is often viewed to arise primarily by genetic alterations. However, today we know that many aspects of the cancer phenotype require a crosstalk among these genetic alterations with epigenetic changes. Indeed, aberrant gene expression patterns, driven by epigenetics are fixed by altered signaling from mutated oncogenes and tumor suppressors to define the PDAC phenotype. This conceptual framework may have significant mechanistic value and could offer novel possibilities for treating patients affected with PDAC. In fact, extensive investigations are leading to the development of small molecule drugs that reversibly modify the epigenome. These new 'epigenetic therapeutics' discussed herein are promising to fuel a new era of studies, by providing the medical community with new tools to treat this dismal disease. |Animals [MESH] |Antineoplastic Agents/*pharmacology [MESH] |Carcinoma, Pancreatic Ductal/*drug therapy/genetics [MESH] |CpG Islands [MESH] |DNA Methylation [MESH] |Epigenesis, Genetic/*drug effects [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH]The promise of epigenomic therapeutics in pancreatic cancer (epmc).pdf DeepDyve Pubget Overpricing