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2018 ; 10
(6
): 1571-1582
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The progress of circular RNAs in various tumors
#MMPMID30018701
Wang D
; Yang S
; Wang H
; Wang J
; Zhang Q
; Zhou S
; He Y
; Zhang H
; Deng F
; Xu H
; Zhong S
; Fu L
; Tang J
Am J Transl Res
2018[]; 10
(6
): 1571-1582
PMID30018701
show ga
Circular RNAs (circRNAs), a novel type of non-coding RNAs, presented as
covalently closed continuous loops. Recent researches had found that circRNAs
could function as microRNA sponges, regulators of gene transcription and encoding
proteins. They were relatively stable and expressed widely in cytoplasm, which
played important roles in carcinogenesis of cancers, such as esophageal cancer,
gastric cancer, colorectal cancer, hepatocarcinoma, bladder cancer, glioma,
breast cancer, osteosarcoma and so on. Furthermore, they were involved in many
biological functions, like cell proliferation, drug resistance, cell cycle,
invasion and metastasis. Therefore, the further studies were meaningful on the
mechanism of cancers and circRNAs. In the review, we will summarize the current
biogenesis of circRNAs and the roles of them in various cancers, which might be a
novel biomarker and therapeutic avenue.