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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Cell+Commun+Signal
2018 ; 12
(1
): 211-216
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gab.com Text
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English Wikipedia
The primary cilium - once a "rudimentary" organelle that is now a ubiquitous
sensory cellular structure involved in many pathological disorders
#MMPMID29218455
Wheatley DN
J Cell Commun Signal
2018[Mar]; 12
(1
): 211-216
PMID29218455
show ga
This article looks mostly at the steps that have led to the primary cilium
finding its place in our understanding of cell biology, developmental biology,
and medical syndromes due to its aberrations. It is a personal account that
stresses, if nothing else, the value of the adage "stick to your guns". My
obsession with this organelle, following on from fascination with the centriole,
has led to a whole career devoted to determining the nature and role of primary
cilia in basic cell biology, which has proved much more important than had been
appreciated for almost a century. They are heavily involved in very many aspects
of cell physiology that have much wider implications with regard to human biology
and probably throughout the animal kingdom. That aberrations, to the surprise of
many researchers in their structure or functioning has led to their being
implicated or perhaps deeply involved in an extraordinary range of medical
conditions. This invitation allows me to raise crucial questions that need
answers regarding the regulation of their genesis, their cache of both
intracellular and extracellular signal, and their association with a multitude of
development processes from embryo to adult status.