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10.1038/ncb3363 http://scihub22266oqcxt.onion/10.1038/ncb3363 C4925210!4925210 !27214281     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27214281 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Cell+Biol 2016 ; 18 (7 ): 752-764 Nephropedia Template TP {{tp|p=27214281 |t=2016. The polycystin complex mediates Wnt/Ca(2+) signalling |pdf=|usr=}}{{27214281 }} gab.com Text The polycystin complex mediates Wnt/Ca(2+) signalling JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27214281 #FOAvip WNT ligands induce Ca(2+) signalling on target cells. PKD1 (polycystin 1) is considered an orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2), a Ca(2+)-permeable ion channel. Inactivating mutations in their genes cause autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic diseases. Here, we show that WNTs bind to the extracellular domain of PKD1 and induce whole-cell currents and Ca(2+) influx dependent on TRPP2. Pathogenic PKD1 or PKD2 mutations that abrogate complex formation, compromise cell surface expression of PKD1, or reduce TRPP2 channel activity suppress activation by WNTs. Pkd2(-/-) fibroblasts lack WNT-induced Ca(2+) currents and are unable to polarize during directed cell migration. In Xenopus embryos, pkd1, Dishevelled 2 (dvl2) and wnt9a act within the same pathway to preserve normal tubulogenesis. These data define PKD1 as a WNT (co)receptor and implicate defective WNT/Ca(2+) signalling as one of the causes of ADPKD. Twit Text FOAVip The polycystin complex mediates Wnt/Ca(2+) signalling ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=27214281 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27214281 #FOAvip English Wikipedia <ref>{{Cite pmid|27214281 }}</ref> The polycystin complex mediates Wnt/Ca(2+) signalling #MMPMID27214281 Kim S ; Nie H ; Nesin V ; Tran U ; Outeda P ; Bai CX ; Keeling J ; Maskey D ; Watnick T ; Wessely O ; Tsiokas L Nat Cell Biol 2016[Jul]; 18 (7 ): 752-764 PMID27214281 show ga WNT ligands induce Ca(2+) signalling on target cells. PKD1 (polycystin 1) is considered an orphan, atypical G-protein-coupled receptor complexed with TRPP2 (polycystin 2 or PKD2), a Ca(2+)-permeable ion channel. Inactivating mutations in their genes cause autosomal dominant polycystic kidney disease (ADPKD), one of the most common genetic diseases. Here, we show that WNTs bind to the extracellular domain of PKD1 and induce whole-cell currents and Ca(2+) influx dependent on TRPP2. Pathogenic PKD1 or PKD2 mutations that abrogate complex formation, compromise cell surface expression of PKD1, or reduce TRPP2 channel activity suppress activation by WNTs. Pkd2(-/-) fibroblasts lack WNT-induced Ca(2+) currents and are unable to polarize during directed cell migration. In Xenopus embryos, pkd1, Dishevelled 2 (dvl2) and wnt9a act within the same pathway to preserve normal tubulogenesis. These data define PKD1 as a WNT (co)receptor and implicate defective WNT/Ca(2+) signalling as one of the causes of ADPKD. |*Wnt Signaling Pathway [MESH] |Animals [MESH] |Calcium/*metabolism [MESH] |Cell Membrane/metabolism [MESH] |Dishevelled Proteins/metabolism [MESH] |Fibroblasts/metabolism [MESH] |Gene Knockdown Techniques [MESH] |Humans [MESH] |Mice [MESH] |Protein Binding [MESH] |TRPP Cation Channels/metabolism [MESH]The polycystin complex mediates Wnt/Ca(2+) signalling (epmc).pdf DeepDyve Pubget Overpricing