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2014 ; 39
(3
): 508-19
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The neurobiology of skeletal pain
#MMPMID24494689
Mantyh PW
Eur J Neurosci
2014[Feb]; 39
(3
): 508-19
PMID24494689
show ga
Disorders of the skeleton are one of the most common causes of chronic pain and
long-term physical disability in the world. Chronic skeletal pain is caused by a
remarkably diverse group of conditions including trauma-induced fracture,
osteoarthritis, osteoporosis, low back pain, orthopedic procedures, celiac
disease, sickle cell disease and bone cancer. While these disorders are diverse,
what they share in common is that when chronic skeletal pain occurs in these
disorders, there are currently few therapies that can fully control the pain
without significant unwanted side effects. In this review we focus on recent
advances in our knowledge concerning the unique population of primary afferent
sensory nerve fibers that innervate the skeleton, the nociceptive and neuropathic
mechanisms that are involved in driving skeletal pain, and the neurochemical and
structural changes that can occur in sensory and sympathetic nerve fibers and the
CNS in chronic skeletal pain. We also discuss therapies targeting nerve growth
factor or sclerostin for treating skeletal pain. These therapies have provided
unique insight into the factors that drive skeletal pain and the structural
decline that occurs in the aging skeleton. We conclude by discussing how these
advances have changed our understanding and potentially the therapeutic options
for treating and/or preventing chronic pain in the injured, diseased and aged
skeleton.
|Anabolic Agents/therapeutic use
[MESH]
|Analgesics/therapeutic use
[MESH]
|Animals
[MESH]
|Bone and Bones/*innervation/physiopathology
[MESH]
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