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2013 ; 3
(10
): a011783
Nephropedia Template TP
gab.com Text
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English Wikipedia
The natural history of sickle cell disease
#MMPMID23813607
Serjeant GR
Cold Spring Harb Perspect Med
2013[Oct]; 3
(10
): a011783
PMID23813607
show ga
The term sickle cell disease embraces a group of genetic conditions in which
pathology results from the inheritance of the sickle cell gene either
homozygously or as a double heterozygote with another interacting gene. The
spectrum of resulting conditions is therefore influenced by the geography of
individual hemoglobin genes, but in most populations, the commonest genotype at
birth is homozygous sickle cell (SS) disease. Because this genotype generally
manifests a greater mortality, the relative proportion of sickle cell genotypes
is influenced by age as well as the geographical distribution of individual
genes.
|Adult
[MESH]
|Africa/ethnology
[MESH]
|Anemia, Sickle Cell/ethnology/*genetics/prevention & control
[MESH]