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10.3350/cmh.2015.21.3.220 http://scihub22266oqcxt.onion/10.3350/cmh.2015.21.3.220 C4612282!4612282 !26523267     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26523267 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26523267 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Clin+Mol+Hepatol 2015 ; 21 (3 ): 220-9 Nephropedia Template TP {{tp|p=26523267 |t=2015. The mutational landscape of hepatocellular carcinoma |pdf=|usr=}}{{26523267 }} gab.com Text The mutational landscape of hepatocellular carcinoma JO: Clin Mol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26523267 #FOAvip The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in genomic technologies have revolutionized the search for genetic alterations in cancer genomes. Recent studies in which all coding exons in HCC were sequenced have shed new light on the genomic landscape of this malignant disease. Catalogues of these somatic mutations and systematic analysis of catalogued mutations will lead us to uncover candidate HCC driver genes, although further functional validation is needed to determine whether these genes play a causal role in the development of HCC. This review provides an overview of previously known oncogenes and new oncogene candidates in HCC that were uncovered from recent exome or whole-genome sequencing studies. This knowledge provides direction for future personalized treatment approaches for patients with HCC. Twit Text FOAVip The mutational landscape of hepatocellular carcinoma ????Clin Mol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=26523267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26523267 #FOAvip English Wikipedia <ref>{{Cite pmid|26523267 }}</ref> The mutational landscape of hepatocellular carcinoma #MMPMID26523267 Lee JS Clin Mol Hepatol 2015[Sep]; 21 (3 ): 220-9 PMID26523267 show ga The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in genomic technologies have revolutionized the search for genetic alterations in cancer genomes. Recent studies in which all coding exons in HCC were sequenced have shed new light on the genomic landscape of this malignant disease. Catalogues of these somatic mutations and systematic analysis of catalogued mutations will lead us to uncover candidate HCC driver genes, although further functional validation is needed to determine whether these genes play a causal role in the development of HCC. This review provides an overview of previously known oncogenes and new oncogene candidates in HCC that were uncovered from recent exome or whole-genome sequencing studies. This knowledge provides direction for future personalized treatment approaches for patients with HCC. |Carcinoma, Hepatocellular/*pathology/therapy [MESH] |Humans [MESH] |Intracellular Signaling Peptides and Proteins/metabolism [MESH] |Liver Neoplasms/*pathology/therapy [MESH] |Mutation [MESH] |Oxidative Stress [MESH] |Precision Medicine [MESH] |Telomerase/metabolism [MESH] |Transcription Factors/genetics/metabolism [MESH]The mutational landscape of hepatocellular carcinoma (epmc).pdf DeepDyve Pubget Overpricing