The multiple facets of alpha-1-antitrypsin
#MMPMID26207223
Stockley RA
Ann Transl Med
2015[Jun]; 3
(10
): 130
PMID26207223
show ga
Alpha-1-antitrypsin (AAT) is recognised as a potent inhibitor of serine
proteinases. Genetic deficiency is associated with several neutrophilic diseases
including severe emphysema. This is believed to reflect the loss of inhibition of
neutrophilic serine proteinases that then result in local tissue damage (the
proteinase/antiprotease hypothesis). In recent years the role of AAT in the
control of inflammatory and immunological processes has become identified.
Although in some instances this may reflect its ability to control
pro-inflammatory effects of serine proteinases it has also become recognised that
it has non proteolytic mediated functions. This poly functional role is starting
to become recognised offering a possibility of its use as a therapeutic agent in
many clinical disease areas. The current review explores both the traditional and
non-traditional function of AAT through published literature.
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