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2016 ; 283
(Pt B
): 541-9
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The multifaceted role of astrocytes in regulating myelination
#MMPMID26988764
K?ray H
; Lindsay SL
; Hosseinzadeh S
; Barnett SC
Exp Neurol
2016[Sep]; 283
(Pt B
): 541-9
PMID26988764
show ga
Astrocytes are the major glial cell of the central nervous system (CNS),
providing both metabolic and physical support to other neural cells. After
injury, astrocytes become reactive and express a continuum of phenotypes which
may be supportive or inhibitory to CNS repair. This review will focus on the
ability of astrocytes to influence myelination in the context of specific
secreted factors, cytokines and other neural cell targets within the CNS. In
particular, we focus on how astrocytes provide energy and cholesterol to neurons,
influence synaptogenesis, affect oligodendrocyte biology and instigate cross-talk
between the many cellular components of the CNS.