The multifaceted biology of plasmacytoid dendritic cells
#MMPMID26160613
Swiecki M
; Colonna M
Nat Rev Immunol
2015[Aug]; 15
(8
): 471-85
PMID26160613
show ga
Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in
the production of type I interferons (IFNs). pDCs promote antiviral immune
responses and have been implicated in the pathogenesis of autoimmune diseases
that are characterized by a type I IFN signature. However, pDCs can also induce
tolerogenic immune responses. In this Review, we summarize recent progress in the
field of pDC biology, focusing on the molecular mechanisms that regulate the
development and functions of pDCs, the pathways involved in their sensing of
pathogens and endogenous nucleic acids, their functions at mucosal sites, and
their roles in infection, autoimmunity and cancer.
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