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2017 ; 18
(1
): 206
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The multidimensional mechanisms of long noncoding RNA function
#MMPMID29084573
Marchese FP
; Raimondi I
; Huarte M
Genome Biol
2017[Oct]; 18
(1
): 206
PMID29084573
show ga
A major shift in our understanding of genome regulation has emerged recently. It
is now apparent that the majority of cellular transcripts do not code for
proteins, and many of them are long noncoding RNAs (lncRNAs). Increasingly,
studies suggest that lncRNAs regulate gene expression through diverse mechanisms.
We review emerging mechanistic views of lncRNAs in gene regulation in the cell
nucleus. We discuss the functional interactions that lncRNAs establish with other
molecules as well as the relationship between lncRNA transcription and function.
While some of these mechanisms are specific to lncRNAs, others might be shared
with other types of genes.