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10.1111/dom.12521 http://scihub22266oqcxt.onion/10.1111/dom.12521 C4562071!4562071 !26332974     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26332974 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26332974 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Diabetes+Obes+Metab 2015 ; 17 Suppl 1 (0 1 ): 99-105 Nephropedia Template TP {{tp|p=26332974 |t=2015. The molecular clock as a metabolic rheostat |pdf=|usr=}}{{26332974 }} gab.com Text The molecular clock as a metabolic rheostat JO: Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=26332974 #FOAvip Circadian clocks are biologic oscillators present in all photosensitive species that produce 24-h cycles in the transcription of rate-limiting metabolic enzymes in anticipation of the light-dark cycle. In mammals, the clock drives energetic cycles to maintain physiologic constancy during the daily switch in behavioural (sleep/wake) and nutritional (fasting/feeding) states. A molecular connection between circadian clocks and tissue metabolism was first established with the discovery that 24-h transcriptional rhythms are cell-autonomous and self-sustained in most tissues and comprise a robust temporal network throughout the body. A major window in understanding how the clock is coupled to metabolism was opened with discovery of metabolic syndrome pathologies in multi-tissue circadian mutant mice including susceptibility to diet-induced obesity and diabetes. Using conditional transgenesis and dynamic metabolic testing, we have pinpointed tissue-specific roles of the clock in energy and glucose homeostasis, with our most detailed understanding of this process in endocrine pancreas. Here, we review evidence for dynamic regulation of insulin secretion and oxidative metabolic functions by the clock transcription pathway to regulate homeostatic responses to feeding and fasting. These studies indicate that clock transcription is a determinant of tissue function and provide a reference for understanding molecular pathologies linking circadian desynchrony to metabolic disease. Twit Text FOAVip The molecular clock as a metabolic rheostat ????Diabetes Obes Metab http://www.kidney.de/pget.php?&tw=1&pmid=26332974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26332974 #FOAvip English Wikipedia <ref>{{Cite pmid|26332974 }}</ref> The molecular clock as a metabolic rheostat #MMPMID26332974 Perelis M ; Ramsey KM ; Bass J Diabetes Obes Metab 2015[Sep]; 17 Suppl 1 (0 1 ): 99-105 PMID26332974 show ga Circadian clocks are biologic oscillators present in all photosensitive species that produce 24-h cycles in the transcription of rate-limiting metabolic enzymes in anticipation of the light-dark cycle. In mammals, the clock drives energetic cycles to maintain physiologic constancy during the daily switch in behavioural (sleep/wake) and nutritional (fasting/feeding) states. A molecular connection between circadian clocks and tissue metabolism was first established with the discovery that 24-h transcriptional rhythms are cell-autonomous and self-sustained in most tissues and comprise a robust temporal network throughout the body. A major window in understanding how the clock is coupled to metabolism was opened with discovery of metabolic syndrome pathologies in multi-tissue circadian mutant mice including susceptibility to diet-induced obesity and diabetes. Using conditional transgenesis and dynamic metabolic testing, we have pinpointed tissue-specific roles of the clock in energy and glucose homeostasis, with our most detailed understanding of this process in endocrine pancreas. Here, we review evidence for dynamic regulation of insulin secretion and oxidative metabolic functions by the clock transcription pathway to regulate homeostatic responses to feeding and fasting. These studies indicate that clock transcription is a determinant of tissue function and provide a reference for understanding molecular pathologies linking circadian desynchrony to metabolic disease. |*Energy Metabolism [MESH] |*Homeostasis [MESH] |Animals [MESH] |Circadian Clocks/*physiology [MESH] |Eating/physiology [MESH] |Fasting/metabolism [MESH] |Glucose/metabolism [MESH] |Humans [MESH] |Insulin Secretion [MESH] |Insulin/metabolism [MESH] |Islets of Langerhans/metabolism [MESH] |Mice [MESH] |Oxidation-Reduction [MESH] |Photoperiod [MESH] |Signal Transduction/physiology [MESH]The molecular clock as a metabolic rheostat (epmc).pdf DeepDyve Pubget Overpricing