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The molecular basis of mechanosensory transduction
#MMPMID22399400
Marshall KL
; Lumpkin EA
Adv Exp Med Biol
2012[]; 739
(?): 142-55
PMID22399400
show ga
Multiple senses, including hearing, touch and osmotic regulation, require the
ability to convert force into an electrical signal: A process called
mechanotransduction. Mechanotransduction occurs through specialized proteins that
open an ion channel pore in response to a mechanical stimulus. Many of these
proteins remain unidentified in vertebrates, but known mechanotransduction
channels in lower organisms provide clues into their identity and mechanism.
Bacteria, fruit flies and nematodes have all been used to elucidate the molecules
necessary for force transduction. This chapter discusses many different
mechanical senses and takes an evolutionary approach to review the proteins
responsible for mechanotransduction in various biological kingdoms.