Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28241138
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28241138
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Nature
2017 ; 543
(7644
): 261-264
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The molecular architecture of lamins in somatic cells
#MMPMID28241138
Turgay Y
; Eibauer M
; Goldman AE
; Shimi T
; Khayat M
; Ben-Harush K
; Dubrovsky-Gaupp A
; Sapra KT
; Goldman RD
; Medalia O
Nature
2017[Mar]; 543
(7644
): 261-264
PMID28241138
show ga
The nuclear lamina is a fundamental constituent of metazoan nuclei. It is
composed mainly of lamins, which are intermediate filament proteins that assemble
into a filamentous meshwork, bridging the nuclear envelope and chromatin. Besides
providing structural stability to the nucleus, the lamina is involved in many
nuclear activities, including chromatin organization, transcription and
replication. However, the structural organization of the nuclear lamina is poorly
understood. Here we use cryo-electron tomography to obtain a detailed view of the
organization of the lamin meshwork within the lamina. Data analysis of individual
lamin filaments resolves a globular-decorated fibre appearance and shows that A-
and B-type lamins assemble into tetrameric filaments of 3.5?nm thickness. Thus,
lamins exhibit a structure that is remarkably different from the other canonical
cytoskeletal elements. Our findings define the architecture of the nuclear lamin
meshworks at molecular resolution, providing insights into their role in
scaffolding the nuclear lamina.
free
free
free
