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10.1016/j.ceb.2014.12.003 http://scihub22266oqcxt.onion/10.1016/j.ceb.2014.12.003 C4380587!4380587 !25543897     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25543897 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Cell+Biol 2015 ; 33 (ä): 74-81 Nephropedia Template TP {{tp|p=25543897 |t=2015. The mitochondrial unfolded protein response?synchronizing genomes |pdf=|usr=}}{{25543897 }} gab.com Text The mitochondrial unfolded protein response synchronizing genomes JO: Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25543897 #FOAvip Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacologically, dysfunction of the proteome is sensed and communicated to the nucleus, where an extensive transcriptional program, aimed to repair the damage, is activated. This feedback loop, termed the mitochondrial unfolded protein response (UPR(mt)), synchronizes the activity of the mitochondrial and nuclear genomes and as such ensures the quality of the mitochondrial proteome. Here we review the recent advances in the UPR(mt) field and discuss its induction, signaling, communication with the other mitochondrial and major cellular regulatory pathways, as well as its potential implications on health and lifespan. Twit Text FOAVip The mitochondrial unfolded protein response synchronizing genomes ????Curr Opin Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=25543897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25543897 #FOAvip English Wikipedia <ref>{{Cite pmid|25543897 }}</ref> The mitochondrial unfolded protein response?synchronizing genomes #MMPMID25543897 Jovaisaite V ; Auwerx J Curr Opin Cell Biol 2015[Apr]; 33 (ä): 74-81 PMID25543897 show ga Maintenance of the mitochondrial proteome is performed primarily by chaperones, which fold and assemble proteins, and by proteases, which degrade excess damaged proteins. Upon various types of mitochondrial stress, triggered genetically or pharmacologically, dysfunction of the proteome is sensed and communicated to the nucleus, where an extensive transcriptional program, aimed to repair the damage, is activated. This feedback loop, termed the mitochondrial unfolded protein response (UPR(mt)), synchronizes the activity of the mitochondrial and nuclear genomes and as such ensures the quality of the mitochondrial proteome. Here we review the recent advances in the UPR(mt) field and discuss its induction, signaling, communication with the other mitochondrial and major cellular regulatory pathways, as well as its potential implications on health and lifespan. |Aging [MESH] |Animals [MESH] |Cell Nucleus/*genetics/metabolism [MESH] |Cytoprotection [MESH] |Genome, Mitochondrial/*genetics [MESH] |Genome/*genetics [MESH] |Humans [MESH] |Mammals [MESH] |Mitochondria/*genetics/*metabolism [MESH] |Mitochondrial Proteins/genetics/*metabolism [MESH] |Proteome/genetics/metabolism [MESH] |Signal Transduction/genetics [MESH]The mitochondrial unfolded protein response?synchronizing genomes (epmc).pdf DeepDyve Pubget Overpricing