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10.1007/s00335-014-9525-z http://scihub22266oqcxt.onion/10.1007/s00335-014-9525-z C4167215!4167215 !24898297     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24898297 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24898297 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mamm+Genome 2014 ; 25 (9-10 ): 424-33 Nephropedia Template TP {{tp|p=24898297 |t=2014. The mitochondrial unfolded protein response in mammalian physiology |pdf=|usr=}}{{24898297 }} gab.com Text The mitochondrial unfolded protein response in mammalian physiology JO: Mamm Genome http://www.kidney.de/pget.php?&tw=1&pmid=24898297 #FOAvip Mitochondria, the main site of cellular energy harvesting, are derived from proteobacteria that evolved within our cells in endosymbiosis. Mitochondria retained vestiges of their proteobacterial genome, the circular mitochondrial DNA, which encodes 13 subunits of the oxidative phosphorylation multiprotein complexes in the electron transport chain (ETC), while the remaining ~80 ETC components are encoded in the nuclear DNA (nDNA). A further ~1,400 proteins, which are essential for mitochondrial function are also encoded in nDNA. Thus, a majority of mitochondrial proteins are translated in the cytoplasm, then imported, processed, and assembled in the mitochondria. An intricate protein quality control (PQC) network, constituted of chaperones and proteases that refold or degrade defective proteins, maintains mitochondrial proteostasis and ensures the cell and organism health. The mitochondrial unfolded protein response is a relatively recently discovered PQC pathway, which senses the proteostatic disturbances specifically in the mitochondria and resolves the stress by retrograde signaling to the nucleus and consequent transcriptional activation of protective genes. This PQC system does not only transiently resolve the local stress but also can have long-lasting effects on whole body metabolism, fitness, and longevity. A delicate tuning of its activation levels might constitute a treatment of various diseases, such as metabolic diseases, cancer, and neurodegenerative disorders. Twit Text FOAVip The mitochondrial unfolded protein response in mammalian physiology ????Mamm Genome http://www.kidney.de/pget.php?&tw=1&pmid=24898297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24898297 #FOAvip English Wikipedia <ref>{{Cite pmid|24898297 }}</ref> The mitochondrial unfolded protein response in mammalian physiology #MMPMID24898297 Mottis A ; Jovaisaite V ; Auwerx J Mamm Genome 2014[Oct]; 25 (9-10 ): 424-33 PMID24898297 show ga Mitochondria, the main site of cellular energy harvesting, are derived from proteobacteria that evolved within our cells in endosymbiosis. Mitochondria retained vestiges of their proteobacterial genome, the circular mitochondrial DNA, which encodes 13 subunits of the oxidative phosphorylation multiprotein complexes in the electron transport chain (ETC), while the remaining ~80 ETC components are encoded in the nuclear DNA (nDNA). A further ~1,400 proteins, which are essential for mitochondrial function are also encoded in nDNA. Thus, a majority of mitochondrial proteins are translated in the cytoplasm, then imported, processed, and assembled in the mitochondria. An intricate protein quality control (PQC) network, constituted of chaperones and proteases that refold or degrade defective proteins, maintains mitochondrial proteostasis and ensures the cell and organism health. The mitochondrial unfolded protein response is a relatively recently discovered PQC pathway, which senses the proteostatic disturbances specifically in the mitochondria and resolves the stress by retrograde signaling to the nucleus and consequent transcriptional activation of protective genes. This PQC system does not only transiently resolve the local stress but also can have long-lasting effects on whole body metabolism, fitness, and longevity. A delicate tuning of its activation levels might constitute a treatment of various diseases, such as metabolic diseases, cancer, and neurodegenerative disorders. |*Unfolded Protein Response [MESH] |Animals [MESH] |Cell Nucleus/metabolism [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Mammals/*physiology [MESH] |Metabolic Diseases/genetics/metabolism [MESH] |Mitochondria/genetics/*metabolism [MESH] |Neoplasms/genetics/metabolism [MESH] |Nervous System Diseases/genetics/metabolism [MESH]The mitochondrial unfolded protein response in mammalian physiology (epmc).pdf DeepDyve Pubget Overpricing