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2013 ; 5
(11
): a012807
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The minichromosome maintenance replicative helicase
#MMPMID23881943
Bell SD
; Botchan MR
Cold Spring Harb Perspect Biol
2013[Nov]; 5
(11
): a012807
PMID23881943
show ga
The eukaryotic replicative helicase, the minichromosome maintenance (MCM)
complex, is composed of six distinct, but related, subunits MCM(2-7). The
relationship between the sequences of the subunits indicates that they are
derived from a common ancestor and indeed, present-day archaea possess a
homohexameric MCM. Recent progress in the biochemical and structural studies of
both eukaryal and archaeal MCM complexes are beginning to shed light on the
mechanisms of action of this key component of the replisome.
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