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10.18632/oncotarget.5294 http://scihub22266oqcxt.onion/10.18632/oncotarget.5294 C4741810!4741810 !26418878     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26418878 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26418878 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2015 ; 6 (32 ): 33893-911 Nephropedia Template TP {{tp|p=26418878 |t=2015. The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear ?-catenin and CD44 |pdf=|usr=}}{{26418878 }} gab.com Text The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear -catenin and CD44 JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26418878 #FOAvip N-myc downstream-regulated gene 1 (NDRG1), has been identified as an important metastasis suppressor for colorectal cancer (CRC). In this study, we investigated: (1) the effects of NDRG1 on CRC stemness and tumorigenesis; (2) the molecular mechanisms involved; and (3) the relationship between NDRG1 expression and colorectal cancer prognosis. Our investigation demonstrated that CRC cells with silenced NDRG1 showed more tumorigenic ability and stem cell-like properties, such as: colony and sphere formation, chemoresistance, cell invasion, high expression of CD44, and tumorigenicity in vivo. Moreover, NDRG1 silencing reduced ?-catenin expression on the cell membrane, while increasing its nuclear expression. The anti-tumor activity of NDRG1 was demonstrated to be mediated by preventing ?-catenin nuclear translocation, as silencing of this latter molecule could reverse the effects of silencing NDRG1 expression. NDRG1 expression was also demonstrated to be negatively correlated to CRC prognosis. In addition, there was a negative correlation between NDRG1 and nuclear ?-catenin and also NDRG1 and CD44 expression in clinical CRC specimens. Taken together, our investigation demonstrates that the anti-metastatic activity of NDRG1 in CRC occurs through the down-regulation of nuclear ?-catenin and suggests that NDRG1 is a significant therapeutic target. Twit Text FOAVip The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear -catenin and CD44 ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26418878 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26418878 #FOAvip English Wikipedia <ref>{{Cite pmid|26418878 }}</ref> The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear ?-catenin and CD44 #MMPMID26418878 Wangpu X ; Yang X ; Zhao J ; Lu J ; Guan S ; Lu J ; Kovacevic Z ; Liu W ; Mi L ; Jin R ; Sun J ; Yue F ; Ma J ; Lu A ; Richardson DR ; Wang L ; Zheng M Oncotarget 2015[Oct]; 6 (32 ): 33893-911 PMID26418878 show ga N-myc downstream-regulated gene 1 (NDRG1), has been identified as an important metastasis suppressor for colorectal cancer (CRC). In this study, we investigated: (1) the effects of NDRG1 on CRC stemness and tumorigenesis; (2) the molecular mechanisms involved; and (3) the relationship between NDRG1 expression and colorectal cancer prognosis. Our investigation demonstrated that CRC cells with silenced NDRG1 showed more tumorigenic ability and stem cell-like properties, such as: colony and sphere formation, chemoresistance, cell invasion, high expression of CD44, and tumorigenicity in vivo. Moreover, NDRG1 silencing reduced ?-catenin expression on the cell membrane, while increasing its nuclear expression. The anti-tumor activity of NDRG1 was demonstrated to be mediated by preventing ?-catenin nuclear translocation, as silencing of this latter molecule could reverse the effects of silencing NDRG1 expression. NDRG1 expression was also demonstrated to be negatively correlated to CRC prognosis. In addition, there was a negative correlation between NDRG1 and nuclear ?-catenin and also NDRG1 and CD44 expression in clinical CRC specimens. Taken together, our investigation demonstrates that the anti-metastatic activity of NDRG1 in CRC occurs through the down-regulation of nuclear ?-catenin and suggests that NDRG1 is a significant therapeutic target. |AC133 Antigen [MESH] |Aged [MESH] |Animals [MESH] |Antigens, CD/metabolism [MESH] |Cell Cycle Proteins/*metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Membrane/metabolism [MESH] |Cell Nucleus/*metabolism [MESH] |Colorectal Neoplasms/*metabolism [MESH] |Down-Regulation [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Gene Silencing [MESH] |Glycoproteins/metabolism [MESH] |HCT116 Cells [MESH] |HT29 Cells [MESH] |Humans [MESH] |Hyaluronan Receptors/*metabolism [MESH] |Intracellular Signaling Peptides and Proteins/*metabolism [MESH] |Lymphatic Metastasis [MESH] |Male [MESH] |Mice [MESH] |Mice, Nude [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Metastasis [MESH] |Neoplasm Transplantation [MESH] |Neoplastic Stem Cells/*cytology [MESH] |Peptides/metabolism [MESH] |Phenotype [MESH] |Prognosis [MESH]The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal ca(epmc).pdf DeepDyve Pubget Overpricing