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2014 ; 12
(6
): 564-74
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The many roles of statins in ischemic stroke
#MMPMID25977681
Zhao J
; Zhang X
; Dong L
; Wen Y
; Cui L
Curr Neuropharmacol
2014[Dec]; 12
(6
): 564-74
PMID25977681
show ga
Stroke is the third leading cause of human death. Endothelial dysfunction,
thrombogenesis, inflammatory and oxidative stress damage, and angiogenesis play
an important role in cerebral ischemic pathogenesis and represent a target for
prevention and treatment. Statins have been found to improve endothelial
function, modulate thrombogenesis, attenuate inflammatory and oxidative stress
damage, and facilitate angiogenesis far beyond lowering cholesterol levels.
Statins have also been proved to significantly decrease cardiovascular risk and
to improve clinical outcome. Could statins be the new candidate agent for the
prevention and therapy in ischemic stroke? In recent years, a vast expansion in
the understanding of the pathophysiology of ischemic stroke and the pleiotropic
effects of statins has occurred and clinical trials involving statins for the
prevention and treatment of ischemic stroke have begun. These facts force us to
revisit ischemic stroke and consider new strategies for prevention and treatment.
Here, we survey the important developments in the non-lipid dependent pleiotropic
effects and clinical effects of statins in ischemic stroke.
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