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2016 ; 43
(2-3
): 419-30
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The many roles of glutamate in metabolism
#MMPMID26323613
Walker MC
; van der Donk WA
J Ind Microbiol Biotechnol
2016[Mar]; 43
(2-3
): 419-30
PMID26323613
show ga
The amino acid glutamate is a major metabolic hub in many organisms and as such
is involved in diverse processes in addition to its role in protein synthesis.
Nitrogen assimilation, nucleotide, amino acid, and cofactor biosynthesis, as well
as secondary natural product formation all utilize glutamate in some manner.
Glutamate also plays a role in the catabolism of certain amines. Understanding
glutamate's role in these various processes can aid in genome mining for novel
metabolic pathways or the engineering of pathways for bioremediation or chemical
production of valuable compounds.