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2017 ; 158
(ä): 112-123
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English Wikipedia
The many faces of the trabecular meshwork cell
#MMPMID27443500
Stamer WD
; Clark AF
Exp Eye Res
2017[May]; 158
(ä): 112-123
PMID27443500
show ga
With the combined purpose of facilitating useful vision over a lifetime, a number
of ocular cells have evolved specialized features not found elsewhere in the
body. The trabecular meshwork (TM) cell at the irido-corneal angle, which is a
key regulator of intraocular pressure, is no exception. Examination of cells in
culture isolated from the human TM has shown that they are unique in many ways,
displaying characteristic features of several different cell types. Thus, these
neural crest derived cells display expression patterns and behaviors typical of
endothelia, fibroblasts, smooth muscle and macrophages, owing to the multiple
roles and two distinct environments where they operate to maintain intraocular
pressure homeostasis. In most individuals, TM cells function normally over a
lifetime in the face of persistent stressors, including phagocytic, oxidative,
mechanical and metabolic stress. Study of TM cells isolated from ocular
hypertensive eyes has shown a compromised ability to perform their daily duties.
This review highlights the many responsibilities of the TM cell and its
challenges, progress in our understanding of TM biology over the past 30 years,
as well as discusses unanswered questions about TM dysfunction that results in
IOP dysregulation and glaucoma.
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