Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28458449
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28458449
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Toxicol+Pathol
2017 ; 30
(2
): 111-123
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The lymphoid system: a review of species differences
#MMPMID28458449
Haley PJ
J Toxicol Pathol
2017[Apr]; 30
(2
): 111-123
PMID28458449
show ga
While an understanding of the structure and function of a generically described
immune system is essential in contemporary biomedicine, it is clear that a
one-size-fits-all approach applied across multiple species is fraught with
contradictions and inconsistencies. Nevertheless, the breakthroughs achieved in
immunology following the application of observations in murine systems to that of
man have been pivotal in the advancement of biology and human medicine. However,
as additional species have been used to further address biologic and safety
assessment questions relative to the structure and function of the immune system,
it has become clear that there are differences across species, gender, age and
strain that must be considered. The meaningfulness of these differences must be
determined on a case-by-case basis. This review article attempts to collect,
consolidate and discuss some of these species differences thereby aiding in the
accurate placement of new observations in a proper immunobiological and
immunopathological perspective.