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10.1016/j.tig.2015.02.009 http://scihub22266oqcxt.onion/10.1016/j.tig.2015.02.009 C4417040!4417040 !25804345     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25804345 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Genet 2015 ; 31 (5 ): 224-31 Nephropedia Template TP {{tp|p=25804345 |t=2015. The laboratory domestication of Caenorhabditis elegans |pdf=|usr=}}{{25804345 }} gab.com Text The laboratory domestication of Caenorhabditis elegans JO: Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=25804345 #FOAvip Model organisms are of great importance to our understanding of basic biology and to making advances in biomedical research. However, the influence of laboratory cultivation on these organisms is underappreciated, and especially how that environment can affect research outcomes. Recent experiments led to insights into how the widely used laboratory reference strain of the nematode Caenorhabditis elegans compares with natural strains. Here we describe potential selective pressures that led to the fixation of laboratory-derived alleles for the genes npr-1, glb-5, and nath-10. These alleles influence a large number of traits, resulting in behaviors that affect experimental interpretations. Furthermore, strong phenotypic effects caused by these laboratory-derived alleles hinder the discovery of natural alleles. We highlight strategies to reduce the influence of laboratory-derived alleles and to harness the full power of C. elegans. Twit Text FOAVip The laboratory domestication of Caenorhabditis elegans ????Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=25804345 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25804345 #FOAvip English Wikipedia <ref>{{Cite pmid|25804345 }}</ref> The laboratory domestication of Caenorhabditis elegans #MMPMID25804345 Sterken MG ; Snoek LB ; Kammenga JE ; Andersen EC Trends Genet 2015[May]; 31 (5 ): 224-31 PMID25804345 show ga Model organisms are of great importance to our understanding of basic biology and to making advances in biomedical research. However, the influence of laboratory cultivation on these organisms is underappreciated, and especially how that environment can affect research outcomes. Recent experiments led to insights into how the widely used laboratory reference strain of the nematode Caenorhabditis elegans compares with natural strains. Here we describe potential selective pressures that led to the fixation of laboratory-derived alleles for the genes npr-1, glb-5, and nath-10. These alleles influence a large number of traits, resulting in behaviors that affect experimental interpretations. Furthermore, strong phenotypic effects caused by these laboratory-derived alleles hinder the discovery of natural alleles. We highlight strategies to reduce the influence of laboratory-derived alleles and to harness the full power of C. elegans. |*Models, Animal [MESH] |Adaptation, Biological/genetics [MESH] |Alleles [MESH] |Animals [MESH] |Caenorhabditis elegans/*genetics [MESH] |Gene-Environment Interaction [MESH]The laboratory domestication of Caenorhabditis elegans (epmc).pdf DeepDyve Pubget Overpricing