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2014 ; 1319
(1
): 1-18
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The journey from stem cell to macrophage
#MMPMID24673186
Pittet MJ
; Nahrendorf M
; Swirski FK
Ann N Y Acad Sci
2014[Jun]; 1319
(1
): 1-18
PMID24673186
show ga
Essential protectors against infection and injury, macrophages can also
contribute to many common and fatal diseases. Here, we discuss the mechanisms
that control different types of macrophage activities in mice. We follow the
cells' maturational pathways over time and space and elaborate on events that
influence the type of macrophage eventually settling a particular destination.
The nature of the precursor cells, developmental niches, tissues, environmental
cues, and other connecting processes appear to contribute to the identity of
macrophage type. Together, the spatial and developmental relationships of
macrophages compose a topo-ontogenic map that can guide our understanding of
their biology.