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10.1016/j.bbalip.2014.10.007 http://scihub22266oqcxt.onion/10.1016/j.bbalip.2014.10.007 C5404383!5404383!25449649     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25449649.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochim+Biophys+Acta 2015 ; 1851 (4): 433-45 Nephropedia Template TP {{tp|p=25449649|t=2015. The isoprostanes?25 years later |pdf=|usr=}}{{25449649}} gab.com Text The isoprostanes 25 years later JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25449649 #FOAvip Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first isoprostane species discovered were isomeric to prostaglandin F2? and were thus termed F2-IsoPs. Since the initial discovery of the F2-IsoPs, IsoPs with differing ring structures have been identified as well as IsoPs from different polyunsaturated fatty acids, including eicosapentaenoic acid and docosahexanenoic acid. The discovery of these molecules in vivo in humans has been a major contribution to the field of lipid oxidation and free radical research over the course of the past 25 years. These molecules have been determined to be both biomarkers and mediators of oxidative stress in numerous disease settings. This review focuses on recent developments in the field with an emphasis on clinical research. Special focus is given to the use of IsoPs as biomarkers in obesity, ischemia-reperfusion injury, the central nervous system, cancer, and genetic disorders. Additionally, attention is paid to diet and lifestyle factors that can affect endogenous levels of IsoPs. This article is part of a Special Issue entitled ?Oxygenated metabolism of PUFA: analysis and biological relevance?. Twit Text FOAVip The isoprostanes 25 years later ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25449649 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25449649 #FOAvip English Wikipedia <ref>{{Cite pmid|25449649}}</ref> The isoprostanes?25 years later #MMPMID25449649 Milne GL; Dai Q; Roberts LJ Biochim Biophys Acta 2015[Apr]; 1851 (4): 433-45 PMID25449649show ga Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first isoprostane species discovered were isomeric to prostaglandin F2? and were thus termed F2-IsoPs. Since the initial discovery of the F2-IsoPs, IsoPs with differing ring structures have been identified as well as IsoPs from different polyunsaturated fatty acids, including eicosapentaenoic acid and docosahexanenoic acid. The discovery of these molecules in vivo in humans has been a major contribution to the field of lipid oxidation and free radical research over the course of the past 25 years. These molecules have been determined to be both biomarkers and mediators of oxidative stress in numerous disease settings. This review focuses on recent developments in the field with an emphasis on clinical research. Special focus is given to the use of IsoPs as biomarkers in obesity, ischemia-reperfusion injury, the central nervous system, cancer, and genetic disorders. Additionally, attention is paid to diet and lifestyle factors that can affect endogenous levels of IsoPs. This article is part of a Special Issue entitled ?Oxygenated metabolism of PUFA: analysis and biological relevance?. äThe isoprostanes?25 years later (epmc).pdf DeepDyve Pubget Overpricing