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10.1093/glycob/cwu067 http://scihub22266oqcxt.onion/10.1093/glycob/cwu067 C4168292!4168292 !24996821     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24996821 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Glycobiology 2014 ; 24 (9 ): 818-25 Nephropedia Template TP {{tp|p=24996821 |t=2014. The interplay between Siglecs and sialylated pathogens |pdf=|usr=}}{{24996821 }} gab.com Text The interplay between Siglecs and sialylated pathogens JO: Glycobiology http://www.kidney.de/pget.php?&tw=1&pmid=24996821 #FOAvip Siglecs are mammalian sialic acid (Sia) recognizing immunoglobulin-like receptors expressed across the major leukocyte lineages, and function to recognize ubiquitous Sia epitopes on cell surface glycoconjugates and regulate immunological and inflammatory activities of these cells. A large subset referred to as CD33-related Siglecs are inhibitory receptors that limit leukocyte activation, and recent research has shown that the pathogen group B Streptococcus (GBS) binds to these Siglecs in Sia- and protein-dependent fashion to downregulate leukocyte bactericidal capacity. Conversely, sialoadhesin is a macrophage phagocytic receptor that engages GBS and other sialylated pathogens to promote effective phagocytosis and antigen presentation for the adaptive immune response. A variety of other important Siglec interactions with bacterial, viral and protozoan pathogens are beginning to be recognized. Siglec genes and binding specificities are rapidly evolving among primates, with key extant polymorphisms in human populations that may influence susceptibility to infection-associated disorders including chronic obstructive pulmonary disease and premature birth. This review summarizes current understanding of interactions between pathogens and Siglecs, a field of investigation that is likely to continue expanding in scope and medical importance. Twit Text FOAVip The interplay between Siglecs and sialylated pathogens ????Glycobiology http://www.kidney.de/pget.php?&tw=1&pmid=24996821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24996821 #FOAvip English Wikipedia <ref>{{Cite pmid|24996821 }}</ref> The interplay between Siglecs and sialylated pathogens #MMPMID24996821 Chang YC ; Nizet V Glycobiology 2014[Sep]; 24 (9 ): 818-25 PMID24996821 show ga Siglecs are mammalian sialic acid (Sia) recognizing immunoglobulin-like receptors expressed across the major leukocyte lineages, and function to recognize ubiquitous Sia epitopes on cell surface glycoconjugates and regulate immunological and inflammatory activities of these cells. A large subset referred to as CD33-related Siglecs are inhibitory receptors that limit leukocyte activation, and recent research has shown that the pathogen group B Streptococcus (GBS) binds to these Siglecs in Sia- and protein-dependent fashion to downregulate leukocyte bactericidal capacity. Conversely, sialoadhesin is a macrophage phagocytic receptor that engages GBS and other sialylated pathogens to promote effective phagocytosis and antigen presentation for the adaptive immune response. A variety of other important Siglec interactions with bacterial, viral and protozoan pathogens are beginning to be recognized. Siglec genes and binding specificities are rapidly evolving among primates, with key extant polymorphisms in human populations that may influence susceptibility to infection-associated disorders including chronic obstructive pulmonary disease and premature birth. This review summarizes current understanding of interactions between pathogens and Siglecs, a field of investigation that is likely to continue expanding in scope and medical importance. |Animals [MESH] |Evolution, Molecular [MESH] |HIV/*immunology [MESH] |Humans [MESH] |Receptors, Immunologic/immunology/metabolism [MESH] |Sialic Acid Binding Immunoglobulin-like Lectins/*immunology/metabolism [MESH] |Sialic Acids/*metabolism [MESH]The interplay between Siglecs and sialylated pathogens (epmc).pdf DeepDyve Pubget Overpricing