The innate immune response in human tuberculosis
#MMPMID26135005
Lerner TR
; Borel S
; Gutierrez MG
Cell Microbiol
2015[Sep]; 17
(9
): 1277-85
PMID26135005
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Mycobacterium tuberculosis (Mtb) infection can be cleared by the innate immune
system before the initiation of an adaptive immune response. This innate
protection requires a variety of robust cell autonomous responses from many
different host immune cell types. However, Mtb has evolved strategies to
circumvent some of these defences. In this mini-review, we discuss these
host-pathogen interactions with a focus on studies performed in human cells
and/or supported by human genetics studies (such as genome-wide association
studies).