Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26170970
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Oncol+Lett
2015 ; 10
(1
): 17-22
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The importance of Src signaling in sarcoma
#MMPMID26170970
Chen Q
; Zhou Z
; Shan L
; Zeng H
; Hua Y
; Cai Z
Oncol Lett
2015[Jul]; 10
(1
): 17-22
PMID26170970
show ga
Src is a tyrosine kinase that is of significance in tumor biology. The present
review focuses on Src, its molecular structure, and role in cancer, in addition
to its expression and function in sarcoma. In addition, the feasibility of Src as
a potential drug target for the treatment of sarcoma is also discussed. Previous
studies have suggested that Src has essential functions in cell proliferation,
apoptosis, invasion, metastasis and the tumor microenvironment. Thus, it may be a
potential target for cancer therapy. Src has been found to enhance proliferation,
reduce apoptosis and promote metastasis in certain subtypes of sarcoma, including
osteosarcoma, chondrosarcoma and Ewing's sarcoma. Furthermore, a number of novel
effective therapeutic agents, such as SI-83, which target Src have been
investigated in vitro and in vivo. Bosutinib and dasatinib, which inhibit Src,
have been approved by the U.S. Food and Drug Administration for the treatment of
chronic myelogenous leukemia. In addition, vandetanib is approved for the
treatment of medullary thyroid cancer. Furthermore, the Src inhibitor,
saracatinib, is currently in clinical trials for the treatment of a variety of
solid tumors, including breast and lung cancers. Thus, Src is considered to be an
important factor in sarcoma progression and may present a novel clinical
therapeutic target. This review demonstrates the importance and clinical
relevance of Src in sarcoma, and discusses a number of small molecular inhibitors
of src kinase, such as dasatinib and sarcatinib, which are currently in clinical
trials for the treatment of sarcoma patients.
free
free
free
