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2011 ; 31
(ä): 33-47
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The implication of brown adipose tissue for humans
#MMPMID21548774
Ravussin E
; Galgani JE
Annu Rev Nutr
2011[Aug]; 31
(ä): 33-47
PMID21548774
show ga
We here discuss the role of brown adipose tissue on energy homeostasis and assess
its potential as a target for body weight management. Because of their high
number of mitochondria and the presence of uncoupling protein 1, brown fat
adipocytes can be termed as energy inefficient for adenosine-5'-triphosphate
(ATP) production but energy efficient for heat production. Thus, the energy
inefficiency of ATP production, despite high energy substrate oxidation, allows
brown adipose tissue to generate heat for body temperature regulation. Whether
such thermogenic property also plays a role in body weight regulation is still
debated. The recent (re)discovery of brown adipose tissue in human adults and a
better understanding of brown adipose tissue development have encouraged the
quest for new alternatives to treat obesity since obese individuals seem to have
less brown adipose tissue mass/activity than do their lean counterparts. In this
review, we discuss the physiological relevance of brown adipose tissue on
thermogenesis and its potential usefulness on body weight control in humans.
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