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2018 ; 10
(2
): 215-218
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The impact of stone composition on renal function
#MMPMID29719337
Nassir A
; Saada H
; Alnajjar T
; Nasser J
; Jameel W
; Elmorsy S
; Badr H
Urol Ann
2018[Apr]; 10
(2
): 215-218
PMID29719337
show ga
BACKGROUND: Nephrolithiasis is a common condition that has various
classifications according to stone composition. Stone formation can affect renal
function; it can be a strong risk factor for chronic kidney disease (CKD). The
main objective of this study is to explore the association between creatinine
clearance and different stone compositions. METHODS: This is a retrospective
cohort study conducted in a tertiary center in Jeddah, Saudi Arabia, between 2005
and 2014. Renal function was assessed by the estimating glomerular filtration
rate (eGFR) by the Cockcroft-Gault equation. Stone composition was determined by
urinary calculi analysis with infrared spectrometry. RESULTS: Stones of 365
patients, with a mean age of 48.2 ± 13.6 years and a male to female ratio of
3.2:1, were analyzed. Stage 2 CKD has been documented. It involved oxalate,
struvite, cystine, and uric acid stones. The worst eGFR was reported for stones
containing uric acid. The eGFR was least affected with apatite stones followed by
brushite stones. CONCLUSION: Stone disease can affect renal function. Different
stone compositions show factor for renal impairment, and this should be
considered in patient management. A special precaution should be considered for
higher risk groups. Multidisciplinary patient care and immediate referral to a
nephrologist are strongly advised.
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