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2017 ; 6
(ä): 611
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The impact of antihypertensives on kidney disease
#MMPMID28529721
Marquez DF
; Ruiz-Hurtado G
; Ruilope L
F1000Res
2017[]; 6
(ä): 611
PMID28529721
show ga
Arterial hypertension and chronic kidney disease (CKD) are intimately related.
The control of blood pressure (BP) levels is strongly recommended in patients
with CKD in order to protect the kidney against the accompanying elevation in
global cardiovascular (CV) risk. Actually, the goal BP in patients with CKD
involves attaining values <140/90 mmHg except if albuminuria is present. In this
case, it is often recommended to attain values <130/80 mmHg, although some
guidelines still recommend <140/90 mmHg. Strict BP control to values of systolic
BP around 120 mmHg was recently shown to be safe in CKD according to data from
the SPRINT trial, albeit more data confirming this benefit are required. Usually,
combination therapy initiated with an angiotensin receptor blocker (ARB) or
angiotensin-converting enzyme inhibitor (ACEi) and commonly followed by the
addition of a calcium channel blocker and a diuretic is needed. Further studies
are required as well as new drugs in particular after the positive data obtained
from new oral anti-diabetic drugs.