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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Opin+Immunol
2015 ; 34
(ä): 59-67
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English Wikipedia
The immunology of influenza virus-associated bacterial pneumonia
#MMPMID25723597
Robinson KM
; Kolls JK
; Alcorn JF
Curr Opin Immunol
2015[Jun]; 34
(ä): 59-67
PMID25723597
show ga
Infection with influenza virus has been a significant cause of morbidity and
mortality for more than a hundred years. Severe disease and increased mortality
often results from bacterial super-infection of patients with influenza virus
infection. Preceding influenza infection alters the host's innate and adaptive
immune responses, allowing increased susceptibility to secondary bacterial
pneumonia. Recent advances in the field have helped to define how influenza
alters the immune response to bacteria through the dysregulation of phagocytes,
antimicrobial peptides, and lymphocytes. Viral-induced interferons play a key
role in altering the phenotype of the immune response. Potential genetic
modifiers of disease will help to define additional immunologic mechanisms that
predispose to viral, bacterial super-infection with the overarching goal of
developing effective therapeutic strategies to prevent and treat disease.