Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26483897
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Sleep+Sci
2014 ; 7
(1
): 19-29
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The hypocretins (orexins) mediate the "phasic" components of REM sleep: A new
hypothesis
#MMPMID26483897
Torterolo P
; Chase MH
Sleep Sci
2014[Mar]; 7
(1
): 19-29
PMID26483897
show ga
In 1998, a group of phenotypically distinct neurons were discovered in the
postero-lateral hypothalamus which contained the neuropeptides hypocretin 1 and
hypocretin 2 (also called orexin A and orexin B), which are excitatory
neuromodulators. Hypocretinergic neurons project throughout the central nervous
system and have been involved in the generation and maintenance of wakefulness.
The sleep disorder narcolepsy, characterized by hypersomnia and cataplexy, is
produced by degeneration of these neurons. The hypocretinergic neurons are active
during wakefulness in conjunction with the presence of motor activity that occurs
during survival-related behaviors. These neurons decrease their firing rate
during non-REM sleep; however there is still controversy upon the activity and
role of these neurons during REM sleep. Hence, in the present report we conducted
a critical review of the literature of the hypocretinergic system during REM
sleep, and hypothesize a possible role of this system in the generation of REM
sleep.