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2015 ; 126
(3
): 311-8
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The human microbiome in hematopoiesis and hematologic disorders
#MMPMID26012569
Manzo VE
; Bhatt AS
Blood
2015[Jul]; 126
(3
): 311-8
PMID26012569
show ga
Humans are now understood to be in complex symbiosis with a diverse ecosystem of
microbial organisms, including bacteria, viruses, and fungi. Efforts to
characterize the role of these microorganisms, commonly referred as the
microbiota, in human health have sought to answer the fundamental questions of
what organisms are present, how are they functioning to interact with human
cells, and by what mechanism are these interactions occurring. In this review, we
describe recent efforts to describe the microbiota in healthy and diseased
individuals, summarize the role of various molecular technologies (ranging from
16S ribosomal RNA to shotgun metagenomic sequencing) in enumerating the community
structure of the microbiota, and explore known interactions between the
microbiota and humans, with a focus on the microbiota's role in hematopoiesis and
hematologic diseases.