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10.1007/s00439-013-1413-1 http://scihub22266oqcxt.onion/10.1007/s00439-013-1413-1 C4024068!4024068 !24390306     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24390306 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24390306 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hum+Genet 2014 ; 133 (6 ): 701-11 Nephropedia Template TP {{tp|p=24390306 |t=2014. The grammar of transcriptional regulation |pdf=|usr=}}{{24390306 }} gab.com Text The grammar of transcriptional regulation JO: Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=24390306 #FOAvip Eukaryotes employ combinatorial strategies to generate a variety of expression patterns from a relatively small set of regulatory DNA elements. As in any other language, deciphering the mapping between DNA and expression requires an understanding of the set of rules that govern basic principles in transcriptional regulation, the functional elements involved, and the ways in which they combine to orchestrate a transcriptional output. Here, we review the current understanding of various grammatical rules, including the effect on expression of the number of transcription factor binding sites, their location, orientation, affinity and activity; co-association with different factors; and intrinsic nucleosome organization. We review different methods that are used to study the grammar of transcription regulation, highlight gaps in current understanding, and discuss how recent technological advances may be utilized to bridge them. Twit Text FOAVip The grammar of transcriptional regulation ????Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=24390306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24390306 #FOAvip English Wikipedia <ref>{{Cite pmid|24390306 }}</ref> The grammar of transcriptional regulation #MMPMID24390306 Weingarten-Gabbay S ; Segal E Hum Genet 2014[Jun]; 133 (6 ): 701-11 PMID24390306 show ga Eukaryotes employ combinatorial strategies to generate a variety of expression patterns from a relatively small set of regulatory DNA elements. As in any other language, deciphering the mapping between DNA and expression requires an understanding of the set of rules that govern basic principles in transcriptional regulation, the functional elements involved, and the ways in which they combine to orchestrate a transcriptional output. Here, we review the current understanding of various grammatical rules, including the effect on expression of the number of transcription factor binding sites, their location, orientation, affinity and activity; co-association with different factors; and intrinsic nucleosome organization. We review different methods that are used to study the grammar of transcription regulation, highlight gaps in current understanding, and discuss how recent technological advances may be utilized to bridge them. |*Gene Expression Regulation [MESH] |*Transcription, Genetic [MESH] |Binding Sites [MESH] |DNA/*genetics/metabolism [MESH] |Humans [MESH] |Protein Binding [MESH] |RNA, Messenger/*genetics/metabolism [MESH] |Regulatory Elements, Transcriptional [MESH] |Sequence Analysis, DNA [MESH] |Sequence Analysis, RNA [MESH]The grammar of transcriptional regulation (epmc).pdf DeepDyve Pubget Overpricing