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10.1007/s11102-017-0789-7

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suck abstract from ncbi


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pmid28161730
      Pituitary 2017 ; 20 (1 ): 10-21
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  • The genetic background of acromegaly #MMPMID28161730
  • Gadelha MR ; Kasuki L ; Korbonits M
  • Pituitary 2017[Feb]; 20 (1 ): 10-21 PMID28161730 show ga
  • Acromegaly is caused by a somatotropinoma in the vast majority of the cases. These are monoclonal tumors that can occur sporadically or rarely in a familial setting. In the last few years, novel familial syndromes have been described and recent studies explored the landscape of somatic mutations in sporadic somatotropinomas. This short review concentrates on the current knowledge of the genetic basis of both familial and sporadic acromegaly.
  • |Acromegaly/etiology/*genetics [MESH]
  • |Female [MESH]
  • |Genetic Background [MESH]
  • |Growth Hormone-Secreting Pituitary Adenoma/complications/genetics [MESH]
  • |Humans [MESH]
  • |Male [MESH]


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